Publications: 2005 – 2009

Below is a list of all publications from 2005 through to 2009. Each texts title, abstract, reference and DOI number are provided for reference.

2009
The Phosphine-Catalyzed Wittig Reaction: A New Vista for Olefin Synthesis?

I. J. S. Fairlamb, ChemSusChem2009, 2, 1021 – 1024

DOI: 10.1002/cssc.200900208


Pd(0)/Cu(I)-Mediated Direct Arylation of 2′-Deoxyadenosines: Mechanistic Role of Cu(I) and Reactivity Comparisons with Related Purine Nucleosides

T. E. Storr, C. G. Baumann, R. T. Thatcher, A. De Ornellas, A. C. Whitwood, I. J. S. Fairlamb, J. Org. Chem. 2009, 74, 16, 5810–5821

DOI: 10.1021/jo9012282


Palladium-Catalysed Cross-Coupling and Related Processes: Some Interesting Observations That Have Been Exploited in Synthetic Chemistry

G. P. McGlacken, I. J. S. Fairlamb, Eur. J. Org. Chem.2009, 4011–4029

DOI: 10.1002/ejoc.200900139


Heteroaromatic Analogues of Dibenzylideneacetone (dba) and Pd02(het-dba)3 Complexes: Effect of a Thienyl Moiety on the Reactivity of Pd0(η2-thn-dba)(PPh3)2/Pd0(PPh3)2 (n = 1 or 2) and Pd0(η2-th2-dba)(dppe)/Pd0(dppe) in Oxidative Addition Reactions with Iodobenzene

P. Sehnal, H. Taghzouti, I. J. S. Fairlamb, A. Jutand, A. F. Lee, A. C. Whitwood, Organometallics 2009, 28, 3, 824–829

DOI: 10.1021/om800975w


Suzuki-Miyaura Cross-Couplings Mediated by trans-PdBr(N-Succ)(PPh3)2: A Convenient Synthetic Method for Diarylmethanes and Aryl(heteroaryl)methanes

P. Sehnal, I. J. S. Fairlamb, R. J. K. Taylor, Synthesis 2009(3): 508-510

DOI: 10.1055/s-0028-1083293


Diversity and design of metal-based carbon monoxide-releasing molecules (CO-RMs) in aqueous systems: revealing the essential trends

W. Zhang, A. J. Atkin, R. J. Thatcher, A. C. Whitwood, I. J. S. Fairlamb, J. M. Lynam, Dalton Trans., 2009, 4351-4358

DOI: 10.1039/B822157J


Ion-tagged π-acidic alkeneligands promote Pd-catalysed allyl–aryl couplings in an ionic liquid

P. S. Bauerlein, I. J. S. Fairlamb, A. G. Jarvis, A. Lee, C. Muller, J. M. Slattery, R. J. Thatcher, D. Vogt, A. C. Whitwood, Chem. Commun., 2009, 5734-5736

DOI: 10.1039/B906823F


N-Heterocyclic carbene coated metal nanoparticles

E. C. Hurst, K. Wilson, I. J. S. Fairlamb, V. Chechik, New J. Chem., 2009,33, 1837-1840

DOI: 10.1039/B905559B


μ2-Alkyne dicobalt(0)hexacarbonyl complexes as carbon monoxide-releasing molecules (CO-RMs): probing the release mechanism

A. J. Atkin, S. Williams, P. Sawle, R. Motterlini, J. M. Lynam, I. J. S. Fairlamb, Dalton Trans., 2009, 3653-3656

DOI: 10.1039/B904627P

2008
A natural light induced regioselective 6π-electrocyclisation–oxidative aromatisation reaction: experimental and theoretical insights

B. E. Moulton, H. Dong, C. T. O’Brien, S. B. Duckett, Z. Lin, I. J. S. Fairlamb, Org. Biomol. Chem., 2008,6, 4523-4532

DOI: 10.1039/B811284C


Synthesis and characterization of new oxazoline-based palladacycles with bridging or terminal imidate ligands. Crystal structures of [{Pd(μ-dibromomaleimidate)(Phox)}2], [Pd(dibromomaleimidate)(Phox)(PPh3)] and [Pd(glutarimidate)(Phox)(PPh3)] (Phox = 2-(2-oxazolinyl)phenyl))

J. S. Serrano, L. Garcia, J. Perez, E. Perez, J. Garcia, G. Sanchez, G. Lopez, I. J. S. Fairlamb, M. Liu, Polyhedron, 2008, 27, 1699

DOI: 10.1016/j.poly.2008.02.001


Site-selective direct arylation of unprotected adenine nucleosides mediated by palladium and copper: insights into the reaction mechanism

T. E. Storr, A. G. Firth, K. Wilson, K. Darley, C. G. Baumann, I. J. S. Fairlamb, Tetrahedron, 2008, 64, 6125

DOI: 10.1016/j.tet.2008.01.062


Structure−Activity Relationships of Methoxychalcones as Inducers of Heme Oxygenase-1

P. Sawle, B. E. Moulton, M. Jarzykowska, C. J. Green, R. Foresi, I. J. S. Fairlamb, R. Motterlini, Chem. Res. Toxicol. 2008, 21, 7, 1484–1494

DOI: 10.1021/tx800115g


A ternary complex of hydroxycinnamoyl-CoA hydratase–lyase (HCHL) with acetyl-CoA and vanillin gives insights into substrate specificity and mechanism

J. P. Bennett, L. Bertin, B. E. Moulton, I. J. S. Fairlamb, M. Brzozowski, N. J. Walton, G. Grogan, Biochem J (2008) 414 (2): 281–289

DOI: 10.1042/BJ20080714


pi-Acidic alkene ligand effects in Pd-catalysed cross-coupling processes: exploiting the interaction of dibenzylidene acetone (dba) and related ligands with Pd0 and PdII

I. J. S. Fairlamb, Org. Biomol. Chem., 2008,6, 3645-3656

DOI: 10.1039/B811772A

2007
η1-2-Pyrone metal carbonyl complexes as CO-releasing molecules (CO-RMs): A delicate balance between stability and CO liberation

I. J. S. Fairlamb, J. M. Lynam, B. E. Moulton, I. E. Taylor, A. K. Duhme-Klair, P. Sawle, R. Motterlini, Dalton Trans., 2007, 3603-3605

DOI: 10.1039/B707377A


Transition metals in organic synthesis: cross-coupling, C–H activation processes and cyclisation strategies

I. J. S. Fairlamb, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2007,103, 68-89

DOI: 10.1039/B614710K


Regioselective (site-selective) functionalisation of unsaturated halogenated nitrogen, oxygen and sulfur heterocycles by Pd-catalysed cross-couplings and direct arylation processes

I. J. S. Fairlamb, Chem. Soc. Rev., 2007,36, 1036-1045

DOI: 10.1039/B611177G


Alkoxy- and amidocarbonylation of functionalised aryl and heteroaryl halides catalysed by a Bedford palladacycle and dppf: a comparison with the primary PdII precursors (PhCN)2PdCl2 and Pd(OAc)2

I. J. S. Fairlamb, S. Grant, P. McCormack, J. Whittall, Dalton Trans., 2007, 859-865

DOI: 10.1039/B615874A


Kill or Cure? Carbon monoxide as a therapeutic agent

I. J. S. Fairlamb, J. M. Lynam, Chemistry Review, 2007, 16, 30-32


Conformational Flexibility in a Carbobicyclic Diphosphinite Ligand

I. J. S. Fairlamb, S. Tommasi, B. E. Moulton, W. Zheng, Z. Lin, A. C. Whitwood, Eur. J. Inorg. Chem.2007, 3173–3178

DOI: 10.1002/ejic.200700484


Chiral Mono- and Bis-annelated Cyclopentadienyl Ligands Derived from Tartaric Acid:  Synthesis of [(η5-Cyclopentadienyl)RuCl(cod)] and [(η5-Cyclopentadienyl)(η6-benzene)Ru]PF6 Derivatives

G. P. McGlacken, C. T. O’Brien, A. C. Whitwood, I. J. S. Fairlamb, Organometallics 2007, 26, 15, 3722–3728

DOI: 10.1021/om700393b


Transition metals in organic synthesis: cross-coupling, C–H activation processes and cyclisation strategies

I. J. S. Fairlamb, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2007,103, 68-89

DOI: 10.1039/B614710K


In-Silico Prediction of Pd-Catalyzed Cross-Coupling Processes:  Dibenzylidene Acetone (dba) Ligand Control

I. J. S. Fairlamb, A. F. Lee, Organometallics 2007, 26, 17, 4087–4089

DOI: 10.1021/om700617r


A Rationale for the Linear Correlation of Aryl Substituent Effects in Fe0 Tricarbonyl Complexes Containing α,β-Unsaturated Enone (Chalcone) Ligands

B. E. Moulton, A. K. Duhme-Klair, I. J. S. Fairlamb, J. M. Lynam, A. C. Whitwood, Organometallics 2007, 26, 25, 6354–6365

DOI: 10.1021/om7006425


Simple PalladiumII Precatalyst for Suzuki−Miyaura Couplings:  Efficient Reactions of Benzylic, Aryl, Heteroaryl, and Vinyl Coupling Partners

M. J. Burns, I. J. S. Fairlamb, A. R. Kapadi, P. Sehnal, R. J. K. Taylor, Org. Lett. 2007, 9, 26, 5397–5400

DOI: 10.1021/ol702291r

2006
η4-Pyrone Fe0carbonyl complexes as effective CO-releasing molecules (CO-RMs)

Fairlamb I.J.S., A. Duhme-Klair, J. M. Lynam, B. E. Moulton, C. T. O’Brien, P. Sawle, J. Hammad, R. Motterlini, Bioorganic & Medicinal Chemistry Letters 2006, 16, 995

DOI: 10.1016/j.bmcl.2005.10.085


Transition metals in organic synthesis: cross-coupling and C–H activation processes

Fairlamb I.J.S., Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2006,102, 50-80

DOI: 10.1039/B515096P


RutheniumII-catalysed cycloisomerisation of 1,6-dienes by focused microwave dielectric heating: improved rates and selectivities leading to exo-methylenecyclopentanes

I. J. S. Fairlamb, G. P. McGlacken, F. Weissberger, Chem. Commun., 2006, 988-990

DOI: 10.1039/B513798E


Regioselectivity in the Sonogashira coupling of 4,6-dichloro-2-pyrone

I. J. S. Fairlamb, C. T. O’Brien, Z. Lin, K. C. Lam, Org. Biomol. Chem., 2006,4, 1213-1216

DOI: 10.1039/B518232H


Ligation independent cloning (LIC) as a rapid route to families of recombinant biocatalysts from sequenced prokaryotic genomes

D. Bronsor, S. F. Butz, J. Solomons, S. Grant, I. J. S. Fairlamb, M. J. Fogg, G. Grogan, Org. Biomol. Chem., 2006,4, 1252-1260

DOI: 10.1039/B517338H


Air stable, phosphine-free anionic palladacyclopentadienyl catalysts: Remarkable halide and pseudohalide effects in Stille coupling

C. M. Crawforth, I. J. S. Fairlamb, A. R. Kapadi, J. L. Serrano, R. J. K. Taylor, G. Sanchez, Adv. Synth. Catal.2006,348, 405 – 412

DOI: 10.1002/adsc.200505325


Influence of the dba Substitution on the Reactivity of Palladium0 Complexes Generated from Pd02(dba-n,n‘-Z)3 or Pd0(dba-n,n‘-Z)2 and PPh3 in Oxidative Addition with Iodobenzene

Y. Mace, A. R. Kapadi, I. J. S. Fairlamb, A. Jutand, Organometallics 2006, 25, 7, 1795–1800

DOI: 10.1021/om0510876


Sonogashira alkynylation of unprotected 8-brominated adenosines and guanosines: fluorescence properties of compact conjugated acetylenes containing a purine ring

A. G. Firth, I. J. S. Fairlamb, K. Darley, C. G. Baumann, Tetrahedron Lett. 2006, 47, 3529

DOI: 10.1016/j.tetlet.2006.03.100


Bioactive Properties of Iron-Containing Carbon Monoxide-Releasing Molecules

P. Sawle, J. Hammad, I. J. S. Fairlamb, B. Moulton, C. T. O’Brien, J. M. Lynam, A. K. Duhme-Klair, R. Foresti, R. Motterlini, J. Pharma. Exp. Thera. 2006, 318, 403

DOI: 10.1124/jpet.106.101758


Effect of the Leaving Ligand X on Transmetalation of Organostannanes (vinylSnR3) with LnPd(Ar)(X) in Stille Cross-Coupling Reactions. A Density Functional Theory Study

A. Ariafard, Z. Lin, I. J. S. Fairlamb, Organometallics 2006, 25, 24, 5788–5794

DOI: 10.1021/om0607705


Exploiting Noninnocent (E,E)-Dibenzylideneacetone (dba) Effects in Palladium0-Mediated Cross-Coupling Reactions: Modulation of the Electronic Properties of dba Affects Catalyst Activity and Stability in Ligand and Ligand-Free Reaction Systems

I. J. S. Fairlamb, A. R. Kapadi, A. F. Lee, G. P. McGlacken, F. Weissburger, A. H. M. de Vries, L. S. de Vondervoort, Chem. Eur. J.2006,12, 8750–8761

DOI: 10.1002/chem.200600473


Phosphinite Ligand Effects in PalladiumII-Catalysed Cycloisomerisation of 1,6-Dienes: Bicyclo[3.2.0]heptanyl Diphosphinite (B[3.2.0]DPO) Ligands Exhibit Flexible Bite Angles, an Effect Derived from Conformational Changes (exo- or endo-Envelope) in the Bicyclic Ligand Scaffold

I. J. S. Fairlamb, S. Grant, S. Tommasi, J. M. Lynam, M. Bandini, H. Dong, Z. Lin, A. C. Whitwood, Adv. Synth. Catal.2006,348, 2515–2530

DOI: 10.1002/adsc.200600346


Halide and pseudohalide effects in Pd-catalysed cross-coupling reactions

I. J. S. Fairlamb, R. K. Taylor, J. L. Serrano, G. Sanchez, New J. Chem., 2006,30, 1695-1704

DOI: 10.1039/B605699G

2005
Halogenated-2-pyrones in Sonogashira cross-coupling: limitations, optimisation and consequences for GC analysis of Pd-mediated reactions

I. J. S. Fairlamb, A. F. Lee, F. E. M. Loe-Mie, E. H. Niemela, C. T. O’Brien, A. C. Whitwood, Tetrahedron, 2005, 61, 9827

DOI: 10.1016/j.tet.2005.07.102


Oxidative addition of N-halosuccinimides to palladium0: the discovery of neutral palladiumII imidate complexes, which enhance Stille coupling of allylic and benzylic halides

C. M. Crawforth, S. Burling, I. J. S. Fairlamb, A. R. Kapadi, R. J. K. Taylor, A. C. Whitwood, Tetrahedron, 2005, 61, 9736

DOI: 10.1016/j.tet.2005.06.080


Palladium catalysis in synthesis: where next?

I. J. S. Fairlamb, Tetrahedron, 2005, 61, 9661

DOI: 10.1016/j.tet.2005.08.002


Synthesis of PdII and PtII complexes possessing bicyclo[3.2.0]heptanyl phosphinite ligands: Identification of a novel PdII precatalyst for 1,6-diene cycloisomerisation

I. J. S. Fairlamb, S. Grant, A. C. Whitwood, J. Whitthall, A. S. Batsanov, J. C. Collings, J. Organ. Chem., 2005, 690, 4462

DOI: 10.1016/j.jorganchem.2005.01.037


2-Pyrone natural products and mimetics: isolation, characterisation and biological activity

G. P. McGlacken, I. J. S. Fairlamb, Nat. Prod. Rep., 2005,22, 369-385

DOI: 10.1039/B416651P


Requirement for an Oxidant in Pd/Cu Co-Catalyzed Terminal Alkyne Homocoupling To Give Symmetrical 1,4-Disubstituted 1,3-Diynes

A. S. Batsanov, J. C. Collings, I. J. S. Fairlamb, J. P. Holland, J. A. K. Howard, Z. Lin, T. B. Marder, A. C. Parsons, R. M. Waed, J. Zhu, J. Org. Chem. 2005, 70, 2, 703–706

DOI: 10.1021/jo048428u


Optical properties of donor–acceptor phenylene-ethynylene systems containing the 6-methylpyran-2-one group as an acceptor

J. C. Collings, A. C. Parsons, L. Porres, A. Beeby, A. S. Batsanov, J. A. K. Howard, D. P. Lyndon, P. J. Low, I. J. S. Fairlamb, T. B. Marder, Chem. Commun., 2005, 2666-2668

DOI: 10.1039/B502781K


Transition metals in organic synthesis

I. J. S. Fairlamb, Annu. Rep. Prog. Chem., Sect. B: Org. Chem., 2005,101, 69-102

DOI: 10.1039/B418975M

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